Runx2 Is a Common Target of Transforming Growth Factor b1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12
نویسندگان
چکیده
10.1128/MCB.20.23.8783-8792.2000. 2000, 20(23):8783. DOI: Mol. Cell. Biol. Suk-Chul Bae Eung-Gook Kim, Je-Young Choi, Hyun-Mo Ryoo and Chisato Ueta, Toshihisa Komori, John M. Wozney, Kyeong-Sook Lee, Hyun-Jung Kim, Qing-Lin Li, Xin-Zi Chi, Mesenchymal Precursor Cell Line C2C12 Gene Expression in the Pluripotent and Smad5 Induces Osteoblast-Specific Protein 2, and Cooperation between Runx2 1 and Bone Morphogenetic β Growth Factor Runx2 Is a Common Target of Transforming
منابع مشابه
Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2.
Runx2 is an osteoblast master transcription factor and a target for bone morphogenetic protein (BMP) signaling, but our knowledge of events downstream of Runx2 is limited. In this study, we used ChIP Display to discover seven novel genomic regions occupied by Runx2 in living MC3T3-E1 osteoblastic cells. Six of these regions are found within or up to 1-kb away from annotated genes, but only two ...
متن کاملبررسی اثر ایزوپرترنول (آگونیست بتا آدرنرژیک) بر تمایز سلول‌های بنیادی مزانشیمی مغز استخوان انسان به استئوبلاست در شرایط آزمایشگاهی
Background and Objective: The importance of β-adrenergic signals in bone formation and resorption has been well investigated. However, little is known about the role of β -adrenergic signals in osteoblastic differentiation of mesenchymal stem cells (MSCs), which is critically important in bone physiology and pharmacology. In this study, RUNX2 and Osteocalcin gene expression were quantified in M...
متن کاملBlocking c-Met signaling enhances bone morphogenetic protein-2-induced osteoblast differentiation
We previously demonstrated that blocking hepatocyte growth factor (HGF) receptor/c-Met signaling inhibited arthritis and articular bone destruction in mouse models of rheumatoid arthritis (RA). In the present study, we investigated the role of c-Met signaling in osteoblast differentiation using the C2C12 myoblast cell line derived from murine satellite cells and the MC3T3-E1 murine pre-osteobla...
متن کاملRegulation of Bone Metabolism
Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...
متن کاملDifferential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype.
Cbfa1/Runx2 is a transcription factor essential for bone formation and osteoblast differentiation. Two major N-terminal isoforms of Cbfa1, designated type I/p56 (PEBP2aA1, starting with the sequence MRIPV) and type II/p57 (til-1, starting with the sequence MASNS), each regulated by distinct promoters, are known. Here, we show that the type I transcript is constitutively expressed in nonosseous ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2000